Ultrasound Transmission Technique as a Potential Tool for Physical Evaluation of Monolithic Matrix Tablets |
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| Authors: | M A Hakulinen J Pajander J Leskinen J Ketolainen B van Veen K Niinimäki K Pirskanen A Poso R Lappalainen |
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| Institution: | (1) Department of Physics, BioMater Centre, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland;(2) Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland;(3) Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland;(4) Orion Pharma R&D, Orion Corporation, P.O. Box 65, 02101 Espoo, Finland |
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| Abstract: | The aim of this study was to investigate the effects of tablet porosity and particle size fraction of compacted Starch acetate
powders, with and without model drug caffeine, on acoustic properties of tablets. The ultrasound velocity was determined from
the transmission measurements. Tablets of starch acetate (SA DS 2.7) powder with two particle size fractions of 0–53 and 0–710 μm
were compressed with a compaction simulator. Porosities of tablets varied in the range from 12% to 43% for both particle size
fractions. Strong associations were found between the ultrasound velocity and physical properties of the tablets such as porosity
and particle size fraction. Interestingly, ultrasound velocity was practically insensitive to inclusion of the model drug
caffeine with the concentrations used. Based on this study ultrasound transmission method is a potential non-destructive tool
for studying structural changes of tablets and other solid dosage forms. |
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| Keywords: | caffeine particle size porosity starch acetate tablet ultrasound velocity |
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