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Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation |
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| Authors: | Kim Tae Hoon Kim Jae Kyung Ito Hideyuki Jo Cheorun |
| Affiliation: | a Department of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan 712-715, Republic of Korea b Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea c Division of Pharmaceutical Sciences, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan d Department of Animal Science and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea |
| Abstract: | The naturally occurring yellow dietary diarylheptanoid curcumin (1) was converted by γ-ray to two new γ-lactones, curculactones A (2) and B (3), as well as four known transformates, erythro-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol (4), threo-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol (5), vanillic acid (6), and vanillin (7). The structures of the two new γ-lactone derivatives were elucidated on the basis of spectroscopic methods. The steroisomeric phenylpropanoids 4 and 5 exhibited significantly enhanced inhibitory activity against pancreatic lipase when compared to parent curcumin. |
| Keywords: | Radiolytic transformation Curcumin γ-Lactones Phenylpropanoids Pancreatic lipase |
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