Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas |
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| Authors: | Peng Hao Liang Yongju Chen Le Fu Liwu Wang Haiqin He Hongwu |
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| Affiliation: | a Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, and College of Chemistry, Central China Normal University, Wuhan 430079, PR China
b State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, PR China |
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| Abstract: | The synthesis and biological activity of 1,3-benzenedicarbonyl dithioureas are described. Bioassay results indicated that these compounds exhibited cytotoxicity against various cancer cells. For example, compounds 4a showed the best inhibition activities against KB and CNE2 with IC50 10.72 and 9.91 μM, respectively. |
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| Keywords: | Synthesis Antitumor activity 1,3-Benzenedicarbonyl dithioureas |
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