Antimalarial activity of 2,4,6-trisubstituted pyrimidines |
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Authors: | Agarwal Anu Srivastava Kumkum Puri S K Chauhan Prem M S |
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Institution: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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Abstract: | A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 microg/mL. These compounds are in vitro several folds more active than pyrimethamine. |
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