Caffeic Acid Phenethyl Ester Exerts a Neuroprotective Effect on CNS Against Pentylenetetrazol-Induced Seizures in Mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Caffeic Acid Phenethyl Ester Exerts a Neuroprotective Effect on CNS Against Pentylenetetrazol-Induced Seizures in Mice

Authors:	Atilla?Ilhan author-information" > author-information__contact u-icon-before" > mailto:ailhan@inonu.edu.tr" title=" ailhan@inonu.edu.tr" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Mustafa?Iraz,Ahmet?Gurel,Ferah?Armutcu,Omer?Akyol

Affiliation:	(1) Departments of Neurology, Medical Faculty, Inonu University, Malatya, Turkey;(2) Medical Faculty, Departments of Pharmacology, Inonu University, Malatya, Turkey;(3) Medical Faculty, Department of Biochemistry, Karaelmas University , Zonguldak, Turkey;(4) Medical Faculty, Departments of Biochemistry, Inonu University, Malatya, Turkey;(5) Medical Faculty, Department of Neurology, Turgut Ozal Medical Center, Inonu University, 44069 Malatya, Turkey

Abstract:	Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.

Keywords:	Caffeic acid phenethyl ester seizure oxidative damage brain
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