首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Nuclear pore dynamics during the cell cycle
Authors:Naoko Imamoto  Tomoko Funakoshi
Institution:Cellular Dynamics Laboratory, Riken Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Abstract:A nuclear pore complex (NPC) is a large protein assembly that mediates the nucleocytoplasmic exchange of molecules. During the cell cycle, NPCs assemble, disassemble, and dynamically change their distribution on assembled nuclear envelope (NE), whereas in post-mitosis, NPCs are extremely stable. Extensive studies on its components, structure, and building blocks allow the study of its assembly and disassembly at the molecular level. Depending on the location that the initial components of this structure are built (e.g. chromatin versus double lipid bilayers of the nuclear envelope), the regulation and the mechanism of the assembly differ. Moreover, cell cycle dynamics of NPC are linked with INM proteins, lamins, lipid membranes, and the cell cycle signal, which show that NPC dynamics are highly regulated processes.
Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号