New reactive extraction systems for separation of bio-succinic acid |
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Authors: | Kurzrock Tanja Weuster-Botz Dirk |
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Institution: | (1) Institute of Biochemical Engineering, Technische Universit?t M?nchen, Boltzmannstr. 15, 85748 Garching, Germany; |
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Abstract: | Biotechnologically produced succinic acid has the potential to displace maleic acid and its uses and to become an important
feedstock for the chemical industry. In addition to optimized production strains and fermentation processes, an efficient
separation of succinic acid from the aqueous fermentation broth is indispensable to compete with the current petrochemical
production processes. In this context, high molecular weight amines are known to be effective extractants for organic acids.
For this reason, as a first step of isolation and purification, the reactive extraction of succinic acid was studied by mixing
aqueous succinic acid solutions with 448 different amine–solvent mixtures as extraction agents (mixer-settler studies). The
extraction agents consist either of one amine and one solvent (208 reactive extraction systems) or two amines and two solvents
(240 reactive extraction systems). Maximum extraction yields of succinic acid from an aqueous solution with 423 mM succinic
acid at pH 2.0 were obtained with more than 95% yield with trihexylamine solved in 1-octanol or with dihexylamine and diisooctylamine
solved in 1-octanol and 1-hexanol. Applying these optimized reactive extraction systems with Escherichia coli fermentation broth resulted in extraction yields of 78–85% due to the increased ionic strength of the fermentation supernatant
and the co-extraction of other organic acids (e.g., lactic acid and acetic acid), which represent typical fermentation byproducts. |
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