Influence of Cell Division on the Degree of Streptomycin Bleaching of Euglena gracilis |
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| Authors: | J. L. MEGO D. E. BUETOW |
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| Affiliation: | Neurosurgery Research Laboratory, Baltimore City Hospitals, Baltimore, Maryland and the Gerontology Branch, NHI, NIH, Department of Health, Education and Welfare, Bethesda, and Baltimore City Hospitals, Baltimore, Maryland |
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| Abstract: | SYNOPSIS. Streptomycin (SM) inhibition of greening of Euglena gracilis , strain z, was studied. The antibiotic was most effective if present during cell division in the absence of light. The next most effective condition was that which allowed cell division in the light, and the least effective conditions were those that allowed only minimal cell division in the dark or light (i.e., under "resting" conditions). In the dark, 20–200 times higher concentrations of SM were required for the same degree of inhibition under resting conditions as under growing conditions. The observation of Kirk ( Biochim. Biophys. Acta , 1962, 56 , 139–51)-that the pH of the resting medium influenced the degree of inhibition–was confirmed. |
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