Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind,randomized clinical trial: Chromium,glucose homeostasis and anthropometry |
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| Institution: | 1. School of Nutrition, Federal University of Goiás, Brazil;2. Graduate Program in Health Sciences, Federal University of Goiás, Brazil;3. Universitary Hospital, Federal University of Goiás, Brazil;4. School of Physical Education, Federal University of Goiás, Brazil;1. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;2. Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;3. Department of Biochemistry and Diet Therapy, Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;1. Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt;2. Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt;3. Department of Clinical Pharmacy, Faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt;4. Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia;1. CCEB, School of Medicine and Public Health, The University of Newcastle and Hunter Medical Research Institute, Kookaburra Close, New Lambton Heights, Newcastle, NSW, Australia;2. Bangladesh University of Health Sciences, Mirpur, Dhaka, Bangladesh;3. Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh;4. University Technology Sydney, Sydney, NSW, Australia;5. Goulburn Valley Health, Shepparton, VIC, Australia;6. Institute of Child and Mother Health (ICMH), Demra, Matuail, Dhaka, Bangladesh;7. Centre for Health and Development (CHAD), West Rampura, Dhaka, Bangladesh;8. Medical College for Women, Uttara, Dhaka, Bangladesh;9. RHAC, the University of Melbourne, Shepparton, VIC 3630, Australia;1. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;2. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;1. Department of Pediatrics, Ain-Shams University, Cairo, Egypt;2. Department of Obstetrics and Gynaecology, Al-Azhar University, Cairo, Egypt |
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| Abstract: | ObjectiveTo evaluate the effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients.Material and methodsFifty-six individuals with type 2 Diabetes were randomized on a double blind clinical trial into three groups: placebo (NC0), 50 μg (NC50) and 200 μg (NC200) of chromium nicotinate. Glucose homeostasis, anthropometry and physical activity intensity were evaluated at the beginning, at day 45 and at day 90. Energy intake was evaluated at the beginning, between the beginning and 45 days, and between days 45 and 90 of the study.ResultsThere were no differences within or between groups for HOMA-IR, waist circumference, body fat percentage, lean body mass percentage and total energy intake during the trial. There was an increase of the HOMA-β in group NC0 (p = 0.0349) and a decrease of 1.08 kg in group NC50 (p = 0.0048) at 90 days. The relation between body mass index, body fat percentage and insulin sensitivity did not change in the placebo and supplemented groups (p > 0.05). In the effect of the intervention, for each 1 cm increase in waist circumference there was an increase of 1.90 ± 0.63 in HOMA-IR (p = 0.0087) and 16.31 ± 5.27% in HOMA-β (p = 0.0073) in group NC200. No difference was seen in the intensity of physical activity within the groups and in the comparison between the supplemented groups (NC50 and NC200) and placebo (NC0) at 90 days. There was an increase in energy expenditure in physical activity at 90 days (p = 0.0371) of intervention in the group subjects NC50. As for total energy intake, there were no differences within or between the groups during the study.Conclusion50 μg and 200 μg supplementation with chromium nicotinate for 90 days did not promote improvements in glucose homeostasis and anthropometry in individuals with type 2 diabetes mellitus. |
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| Keywords: | Clinical trial Chromium Insulin resistance Body weight |
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