Levels of l-ascorbic acid and cadmium in the saphenous vein of patients with coronary artery disease are negatively correlated |
| |
| Affiliation: | 1. Department of Biophysics, Medical University of Bialystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland;2. Institute of Health Care, Higher Vocational School of Suwałki, Poland;3. Department of Cardiac Surgery, Medical University of Bialystok, Poland and Department of Cardiac Surgery and The Regional Specialist Hospital in Olsztyn, Poland;1. Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan;2. Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan;3. Raleigh, NC 27709, USA;1. Department of Pathology, University of Western Ontario, Canada;2. Department of Chemistry, University of Western Ontario, Canada;1. Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, Quartier Hopital, Avenue Hippocrate 15, 4000, Liège, Belgium;2. Laboratory for the Analysis of Medicines, CIRM, University of Liège, Quartier Hopital, Avenue Hippocrate 15, 4000, Liège, Belgium |
| |
| Abstract: | BackgroundThe aim of this study was the simultaneous determination of levels of cadmium and l-ascorbic Acid (AA) in human saphenous vein (SV) used in coronary artery bypass grafting (CABG) and check whether there is a relationship between these levels.MethodsHuman SV were collected from 40 patients (20 men and 20 women; age, 40–75 years) at the time of routine coronary artery surgical revascularization. The concentration of cadmium in the tissue was determined according to the GF AAS—atomic absorption method. The concentration of AA was assayed in supernatant by FIA method with spectrophotometric detection.ResultsAA concentration (mean ± SD); men: 98,7 ± 13,18 μg/g tissue, women: 96,06 ± 11,98 μg/g tissue. Cadmium concentration(mean ± SD); men: 309 ± 103,71 ng/g tissue, women: 348,5 ± 255,71 ng/g tissue. Correlations among concentrations of AA and cadmium were insignificant negative in the group of men (Pearson r = −0,1504, p = 0,5269) and in the group women (Pearson r = −0339, p = 0144).ConclusionsNegative correlations among concentrations of AA and cadmium in human SV obtained in our study may indicate a protective effect of this vitamin in relation to toxic cadmium. |
| |
| Keywords: | Ascorbic acid Cadmium Level Saphenous vein |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
