Crystal structure analysis of N-acetylated proline and ring size analogs |
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Authors: | Tobias Schnitzer Nils Trapp Lisa-Marie Fischer Helma Wennemers |
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Institution: | Laboratory of Organic Chemistry, ETH Zürich, D-CHAB, Zurich, Switzerland |
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Abstract: | Crystal structures of N-acetylated proline and homologs with four- and six-membered rings (azetidine carboxylic acid and piperidine carboxylic acid) were obtained and compared. The distinctly different conformations of the four-, five-, and six-membered rings reflect Bayer strain, n → π* interaction, and allylic strain, and result in crystal lattices with a zigzag structure. |
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Keywords: | amino acids conformation crystals proline |
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