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Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA
Authors:Ryoji Suno  Kanako Terakado Kimura  Takanori Nakane  Keitaro Yamashita  Junmei Wang  Takaaki Fujiwara  Yasuaki Yamanaka  Dohyun Im  Shoichiro Horita  Hirokazu Tsujimoto  Maki S Tawaramoto  Takatsugu Hirokawa  Eriko Nango  Kensuke Tono  Takashi Kameshima  Takaki Hatsui  Yasumasa Joti  Makina Yabashi  Takuya Kobayashi
Institution:1. Department of Medical Chemistry and Cell Biology, Graduate School of Medicine, Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan;2. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan;3. RIKEN SPring-8 Center, Hyogo 679-5148, Japan;4. Department of Pharmaceutical Sciences, School of Pharmacy, The University of Pittsburgh, Pittsburgh, PA 15261, USA;5. Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan;6. Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan;7. Japan Synchrotron Radiation Research Institute (JASRI), Hyogo 679-5198, Japan;8. Bioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1, Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan;9. Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;10. Japan Science and Technology Agency, Research Acceleration Program, Membrane Protein Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan;11. Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
Abstract:
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  • Keywords:GPCR  serial femtosecond crystallography  orexin receptor  subtype selective ligand  X-ray crystallography  X-ray free-electron laser
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