Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells |
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| Authors: | Xin Wei Zhi Dai Jing Yang Afsar Khan Hao-Fei Yu Yun-Li Zhao Yi-Fen Wang Ya-Ping Liu Zi-Feng Yang Wan-Yi Huang Xin-Hua Wang Xu-Dong Zhao Xiao-Dong Luo |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People’s Republic of China;3. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;4. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China;5. Guangzhou Medical University, Guangzhou 511436, People’s Republic of China |
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| Abstract: | Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-α), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells. |
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| Keywords: | Alstoniasidines A and B Sugar bridged bisindole Glioma stem cells Corresponding authors at: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China (X.-D. Luo). |
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