Exploiting polarity and chirality to probe the Hsp90 C-terminus |
| |
Authors: | Leah K. Forsberg Rachel E. Davis Virangika K. Wimalasena Brian S.J. Blagg |
| |
Affiliation: | Department of Chemistry and Biochemistry, University of Notre Dame, 305 McCourtney Hall, Notre Dame, IN 46556 USA |
| |
Abstract: | Inhibition of the Hsp90 C-terminus is an attractive therapeutic approach for the treatment of cancer. Novobiocin, the first Hsp90 C-terminal inhibitor identified, contains a synthetically complex noviose sugar that has limited the generation of structure-activity relationships for this region of the molecule. The work described herein utilizes various ring systems as noviose surrogates to explore the size and nature of the surrounding binding pocket. |
| |
Keywords: | Corresponding author. |
本文献已被 ScienceDirect 等数据库收录! |
|