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A short synthesis of Dronedarone |
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| Authors: | Barbara Piotrkowska Sven Nerdinger Erwin Schreiner Lovro Selič Piotr P Graczyk |
| Institution: | 1. Selvita Services sp. z o.o., Bobrzynskiego 14, Krakow 30-348, Poland;2. Sandoz GmbH, Biochemiestr. 10, Kundl A-6550, Austria;3. Lek Pharmaceutical, Kolodvorska 27, Menge? 1234, Slovenia |
| Abstract: | A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R?=?CH2CH2CH2NBu2) in a two-stage process in almost 55% overall yield. Our results represent significant improvement over other state-of-the-art methods as no extra steps for the decoration of the benzofuran core are required. |
| Keywords: | Dronedarone Optimization Nenitzescu Quinonimine |
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