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Development of a safe and scalable route towards a tau PET tracer precursor |
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| Authors: | Bjoern Bartels Philipp Cueni Dieter Muri Matthias Koerner | |
| Institution: | Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland | |
| Abstract: | A scalable 5-step synthesis of the diazacarbazole derivative 1 used as tau PET tracer precursor is reported. Key features of this synthesis include a Buchwald-Hartwig amination, a Pd catalyzed C | |
| Keywords: | calcd calculated h hour(s) IPC in-process control min minutes NFT neurofibrillary tangle NSB non-specific binding NT neutropil thread r t ambient (room) temperature Diazacarbazole Direct arylation PET tracer Tau | |
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