Synthesis,structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors |
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Authors: | Ehsan Ullah Mughal Asif Javid Amina Sadiq Shahzad Murtaza Muhammad Naveed Zafar Bilal Ahmad Khan Sajjad Hussain Sumrra Muhammad Nawaz Tahir Khalid Mohammed Khan |
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Affiliation: | 1. Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan;2. Department of Chemistry, Govt. College Women University, Sialkot 51300, Pakistan;3. Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan;4. Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan;5. Department of Physics, University of Sargodha, Sargodha, Pakistan;6. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan;g. Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia |
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Abstract: | The prime objective of this research work is to prepare readily soluble synthetic analogues of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various substituents on biological properties of synthetic compounds. In this context, a series of varyingly substituted 3-O-flavonol glycosides have been designed, synthesized and characterized efficiently. The structures of synthetic molecules were unambiguously corroborated by IR, 1H, 13C NMR and ESI-MS spectroscopic techniques. The structure of compound 22 was also analyzed by X-ray diffraction analysis. All the synthetic compounds (21–30) were evaluated for in vitro inhibitory potential against cholinesterase enzymes. The results displayed that most of the derivatives were potent inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with varying degree of IC50 values. The experimental results were further encouraged by molecular docking studies in order to explore their binding behavior with the active pocket of AChE and BChE enzymes. The experimental and theoretical results are in parallel with one another. |
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Keywords: | Flavonoids Flavonols 3-Hydroxyflavones Glycosides Cholinesterases AChE/BChE inhibitors Molecular docking studies |
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