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Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation |
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| Authors: | Ayşegül Özen Lionel Rougé Charlene Bashore Brian R Hearn Nicholas J Skelton Erin C Dueber |
| Institution: | 1. Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, CA 94080, USA;2. Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA;3. Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA;4. Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, CA 94618, USA |
| Abstract: |  |
| Keywords: | USP7 protein engineering deubiquinating enzymes Rosetta molecular dynamics |
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