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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
Authors:Hongwei Lv  Guishuai Lv  Cian Chen  Qianni Zong  Guoqing Jiang  Dan Ye  Xiuliang Cui  Yufei He  Wei Xiang  Qin Han  Liang Tang  Wen Yang  Hongyang Wang
Affiliation:1. International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;2. National Center for Liver Cancer, Second Military Medical University, Shanghai 201805, China;3. Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, China;4. Molecular and Cell Biology Lab, Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China;5. Cancer Research Center, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China;6. Fudan University Shanghai Cancer Center, Shanghai 200032, China;7. Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Shanghai 200438, China;8. Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Shanghai 200438, China
Abstract:
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  • Keywords:NAMPT  PD-L1  immune checkpoint blockade  Tet1  epigenetics  interferon γ  cancer immune evasion  cancer immunotherapy
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