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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
Authors:Abigail S. Krall  Peter J. Mullen  Felicia Surjono  Milica Momcilovic  Ernst W. Schmid  Christopher J. Halbrook  Apisadaporn Thambundit  Steven D. Mittelman  Costas A. Lyssiotis  David B. Shackelford  Simon R.V. Knott  Heather R. Christofk
Affiliation:1. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA;2. Department of Biomedical Sciences, Cedars-Sinai Medical Institute, Los Angeles, CA 90048, USA;3. Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA;4. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA;5. Division of Pediatric Endocrinology, UCLA Children’s Discovery and Innovation Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA;6. University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA;7. Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA;8. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA;9. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:asparagine  respiration  cancer metabolism  metformin  asparaginase  dietary restriction  cancer treatment
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