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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
Authors:Abigail S Krall  Peter J Mullen  Felicia Surjono  Milica Momcilovic  Ernst W Schmid  Christopher J Halbrook  Apisadaporn Thambundit  Steven D Mittelman  Costas A Lyssiotis  David B Shackelford  Simon RV Knott  Heather R Christofk
Institution:1. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA;2. Department of Biomedical Sciences, Cedars-Sinai Medical Institute, Los Angeles, CA 90048, USA;3. Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA;4. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA;5. Division of Pediatric Endocrinology, UCLA Children’s Discovery and Innovation Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA;6. University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA;7. Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA;8. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA;9. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:asparagine  respiration  cancer metabolism  metformin  asparaginase  dietary restriction  cancer treatment
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