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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition |
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| Authors: | Sergio Crespo-Garcia Pamela R. Tsuruda Agnieszka Dejda Rathi D. Ryan Frederik Fournier Shawnta Y. Chaney Frederique Pilon Taner Dogan Gael Cagnone Priyanka Patel Manuel Buscarlet Sonali Dasgupta Gabrielle Girouard Surabhi R. Rao Ariel M. Wilson Robert O’Brien Rachel Juneau Vera Guber Przemyslaw Sapieha |
| Affiliation: | 1. Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada;2. UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA;3. Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada;4. Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada |
| Abstract: |  |
| Keywords: | cellular senescence retinopathy angiogenesis BCL-xL UBX1967 retina diabetes senolytic aging |
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