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Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity
Authors:Yao He  Liuhui Fu  Yiping Li  Wenyan Wang  Mingli Gong  Jing Zhang  Xin Dong  Jiaoyan Huang  Quanbo Wang  Charles R. Mackay  Yang-Xin Fu  Yun Chen  Xiaohuan Guo
Affiliation:1. Institute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China;2. Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing 100084, China;3. School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China;4. Department of Microbiology, Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne 3800, Australia;5. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA;6. Department of Immunology, Key Laboratory of Immune Microenvironment and Disease, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China;7. Research center for clinical oncology, Jiangsu Cancer Hospital, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210018, China
Abstract:
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  • Keywords:gut microbial metabolites  butyrate  antitumor therapy efficacy  CD8+ T cell  ID2  IL-12
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