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Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells
Authors:Effie E. Bastounis  Francisco Serrano-Alcalde  Prathima Radhakrishnan  Patrik Engström  María J. Gómez-Benito  Mackenzi S. Oswald  Yi-Ting Yeh  Jason G. Smith  Matthew D. Welch  José M. García-Aznar  Julie A. Theriot
Affiliation:1. Department of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA;2. Department of Mechanical Engineering, University of Zaragoza, Zaragoza 50009, Spain;3. Biophysics Program, Stanford University, Stanford, CA 94305, USA;4. Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA;5. Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA;6. Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093, USA
Abstract:
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  • Keywords:cell competition  cell mechanics  traction forces  adhesions  epithelial cells  innate immunity  cell extrusion  infection focus
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