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RANK links senescence to stemness in the mammary epithelia,delaying tumor onset but increasing tumor aggressiveness
Authors:Sandra Benítez  Alex Cordero  Patricia G. Santamaría  Jaime Redondo-Pedraza  Ana S. Rocha  Alejandro Collado-Solé  Maria Jimenez  Adrian Sanz-Moreno  Guillermo Yoldi  Juliana C. Santos  Ilaria De Benedictis  Clara Gómez-Aleza  Sabela Da Silva-Álvarez  Kevin Troulé  Gonzalo Gómez-López  Noelia Alcazar  Ignacio Palmero  Manuel Collado  Eva Gonzalez-Suarez
Affiliation:1. Oncobell, Bellvitge Biomedical Research Institute, IDIBELL, 08908 Barcelona, Spain;2. Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;3. Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain;4. Centro de Investigación Biomédica en Red, Área de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid 28029, Spain;5. German Mouse Clinic, Institute of Experimental Genetics, HMGU, Neuherberg, 85764, Germany;6. Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), E15706 Santiago de Compostela, Spain;7. Institute for Research in Biomedicine (IRB), 08028 Barcelona, Spain;8. Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC-UAM, 28029 Madrid, Spain;9. Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
Abstract:
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  • Keywords:breast cancer  mammary gland  receptor activator of NFkB  senescence  senolytics  stemness  metastasis
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