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Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation
Authors:Wanchun Yang  Dejiang Pang  Mina Chen  Chongyangzi Du  Lanlan Jia  Luoling Wang  Yunling He  Wanxiang Jiang  Liping Luo  Zongyan Yu  Mengqian Mao  Qiuyun Yuan  Ping Tang  Xiaoqiang Xia  Yiyuan Cui  Bo Jing  Alexander Platero  Yanhui Liu  Bo Xiao
Affiliation:1. Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China;2. Department of Biology, School of Life Sciences, Brain Research Center, Southern University of Science and Technology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Shenzhen 518055, People’s Republic of China;3. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China;4. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Abstract:
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  • Keywords:neuroenergetics  neuronal activity  Rheb  mitochondria  pyruvate dehydrogenase  mTORC1
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