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Adhesion-mediated mechanosignaling forces mitohormesis
Authors:Kevin M. Tharp  Ryo Higuchi-Sanabria  Greg A. Timblin  Breanna Ford  Carlos Garzon-Coral  Catherine Schneider  Jonathon M. Muncie  Connor Stashko  Joseph R. Daniele  Andrew S. Moore  Phillip A. Frankino  Stefan Homentcovschi  Sagar S. Manoli  Hao Shao  Alicia L. Richards  Kuei-Ho Chen  Johanna ten Hoeve  Gregory M. Ku  Valerie M. Weaver
Affiliation:1. Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA;2. Department of Molecular & Cellular Biology, Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94597, USA;3. Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA;4. Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA;5. Novartis, Berkeley Center for Proteomics and Chemistry Technologies and Department of Chemistry, University of California Berkeley, Berkeley, CA 94720, USA;6. Chemical Engineering Department, Stanford University, Stanford, CA 94305, USA;7. MD Anderson Cancer Center, South Campus Research, Houston, CA 77054, USA;8. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA;9. Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA;10. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA;11. Quantitative Biosciences Institute (QBI), J. David Gladstone Institutes, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA;12. UCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA;13. Diabetes Center, Division of Endocrinology and Metabolism, Department of Medicine, UCSF, San Francisco, CA 94143, USA;14. Department of Bioengineering and Therapeutic Sciences and Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and The Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
Abstract:
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  • Keywords:metabolism  cancer  aging  UPRmt  oxidative stress  extracellular matrix  adhesion  mechanical stress  tension  mechanotabolism
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