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Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment
Authors:Sophie M. Poznanski  Kanwaldeep Singh  Tyrah M. Ritchie  Jennifer A. Aguiar  Isabella Y. Fan  Ana L. Portillo  Eduardo A. Rojas  Fatemeh Vahedi  Abdullah El-Sayes  Sansi Xing  Martin Butcher  Yu Lu  Andrew C. Doxey  Jonathan D. Schertzer  Hal W. Hirte  Ali A. Ashkar
Affiliation:1. Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada;2. Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada;3. Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada;4. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada;5. Juravinski Cancer Centre & McMaster University, Hamilton, ON L8V 5C2, Canada;6. Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4K1, Canada;7. Division of Medical Oncology, Juravinski Cancer Centre, Hamilton, ON L8V 5C2, Canada
Abstract:
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  • Keywords:NK cells  NK cell metabolism  tumor microenvironment  cancer immunotherapy  adoptive cell therapy  immunometabolism  metabolic flexibility  glucose metabolism  Warburg effect  oxidative stress
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