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A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Authors:Nasa Sinnott-Armstrong  Isabel S Sousa  Samantha Laber  Elizabeth Rendina-Ruedy  Simon E Nitter Dankel  Teresa Ferreira  Gunnar Mellgren  David Karasik  Manuel Rivas  Jonathan Pritchard  Anyonya R Guntur  Roger D Cox  Cecilia M Lindgren  Hans Hauner  Richard Sallari  Clifford J Rosen  Yi-Hsiang Hsu  Eric S Lander  Melina Claussnitzer
Institution:1. Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;2. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. Cell Circuits and Epigenomics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;4. Department of Genetics, Stanford University, Stanford 94305 CA, USA;5. Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising 85354, Germany;6. Big Data Institute, University of Oxford, Oxford, UK;7. Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA;8. University of Bergen, Bergen 5020, Norway;9. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway;10. Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5021 Bergen, Norway;11. Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, MA 02131, USA;12. Faculty of Medicine of the Galilee, Bar-Ilan University, Safed, Israel;13. Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA;14. Department of Biology, Stanford University, Stanford, CA 94305, USA;15. Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Freising 85354, Germany;16. Clinical Cooperation Group “Nutrigenomics and Type 2 Diabetes” of the German Center of Diabetes Research, Helmholtz Center Munich, Munich 85764, Germany;17. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA;18. Department of Biology, MIT, Cambridge, MA 02142, USA;19. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA;20. Medical Research Council Harwell, Oxfordshire, UK;21. University of Hohenheim, Institute of Nutritional Science, Stuttgart 70599, Germany
Abstract:
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  • Keywords:variant-to-function study  pleiotropy of type 2 diabetes and bone mineral density  osteoblast and adipocyte metabolism  regulatory genomics  CRISPR-Cas9 variant editing
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