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Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells
Authors:Yan Gong  Ziqi Li  Shitian Zou  Daizhao Deng  Pinglin Lai  Hongling Hu  Yongzhou Yao  Le Hu  Sheng Zhang  Kai Li  Tiantian Wei  Xiaoyang Zhao  Guozhi Xiao  Zifeng Chen  Yu Jiang  Xiaochun Bai  Zhipeng Zou
Institution:1. Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China;2. State Key Laboratory of Organ Failure Research, Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China;3. Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China;4. Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment and School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China;5. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA;6. Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China;7. Department of Orthopedic Trauma, Panyu District Central Hospital of Guangzhou, Guangzhou 511400, China
Abstract:
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  • Keywords:lysosome  MSC  osteogenesis  Vangl2  LAMP-2A  autophagy  osteoblast
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