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Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
Authors:Tim Gruber  Chenchen Pan  Raian E. Contreras  Tobias Wiedemann  Donald A. Morgan  Alicja A. Skowronski  Sandrine Lefort  Cahuê De Bernardis Murat  Ophelia Le Thuc  Beata Legutko  Francisco J. Ruiz-Ojeda  María de la Fuente-Fernández  Angel Luis García-Villalón  Daniel González-Hedström  Melanie Huber  Klara Szigeti-Buck  Timo D. Müller  Siegfried Ussar  Cristina García-Cáceres
Affiliation:1. Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany;2. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany;3. Institute for Advanced Studies, Technische Universität, 85748 Garching, Germany;4. Institute for Tissue Engineering and Regenerative Medicine (ITERM), Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany;5. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University of Munich (LMU), 81377 Munich, Germany;6. Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, 85764 Neuherberg, Germany;7. Neurobiology of Diabetes, TUM School of Medicine, Technical University Munich, 80333 Munich, Germany;8. Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany;9. Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, USA;10. Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY, USA;11. RG Adipocytes & Metabolism, Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany;12. Physiology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;13. Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA;14. Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, Tübingen, Germany;15. Department of Medicine, Technische Universität, Munich, Germany;16. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA;17. Division of Metabolic Diseases, Department of Medicine, Technische Universität, Munich, Germany;18. Medizinische Klinik and Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany
Abstract:
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  • Keywords:obesity  hypertension  leptin  hypothalamus  angiogenesis  astrocytes  HIF1α-VEGF
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