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VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway
Authors:Ming Jiang  Yinshan Fang  Yu Li  Huachao Huang  Zichen Wei  Xia Gao  Hoon-Ki Sung  Jim Hu  Li Qiang  Jian Ruan  Qixuan Chen  Dianhua Jiang  Jeffrey A Whitsett  Xingbin Ai  Jianwen Que
Institution:1. National Clinical Research Center for Child Health of the Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310058 Zhejiang, P.R. China;2. Columbia Center for Human Development & Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, NY 10032, USA;3. Tianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin 300350, P.R. China;4. Translation Medicine Program, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;5. Department of Pathology and Cell Biology, Naomi Berrie Diabetes Center, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA;6. Department of Medical Oncology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003 Zhejiang, P.R. China;7. Mailman School of Public Health, Columbia University, New York, NY, USA;8. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, 90048 CA, USA;9. Department of Pediatrics, University of Cincinnati and Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA;10. Division of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA 02114, USA;11. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, NY 10032, USA
Abstract:
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  • Keywords:mucous cell  club cell  KDR  VEGFR2  VEGFa  Sox9  airway  regeneration  MAPK  goblet cell
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