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PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay
Authors:Archna Ravi  Lavinia Palamiuc  Ryan M. Loughran  Joanna Triscott  Gurpreet K. Arora  Avi Kumar  Vivian Tieu  Chantal Pauli  Matthias Reist  Rachel J. Lew  Shauna L. Houlihan  Christof Fellmann  Christian Metallo  Mark A. Rubin  Brooke M. Emerling
Affiliation:1. Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA;2. Department of Biomedical Research and Bern Center for Precision Medicine, University of Bern and Inselspital Bern, Bern 3008, Switzerland;3. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA;4. Institute of Pathology and Molecular Pathology, University Hospital Zürich and the University of Zurich (UZH), Zurich 8006, Switzerland;5. Gladstone Institutes, San Francisco, CA 94158, USA;6. Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;7. Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA
Abstract:
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  • Keywords:lipid  phosphoinositide  phosphoinositide kinase  PI-5-P  PI5P4Ks  peroxisome  mitochondria  fatty acid  lipid droplet  metabolism  β-oxidation  sarcoma  cancer
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