A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines |
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| Authors: | Moghaddam Amin Olszewska Wieslawa Wang Belinda Tregoning John S Helson Rebecca Sattentau Quentin J Openshaw Peter J M |
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| Affiliation: | Sir William Dunn School of Pathology, The University of Oxford, South Parks Road, Oxford OX1 3RE, UK. |
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| Abstract: | Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with atypical enhanced disease during subsequent infection with paramyxoviruses. We show that carbonyl groups on formaldehyde-treated vaccine antigens boost T helper type 2 (T(H)2) responses and enhance respiratory syncytial virus (RSV) disease in mice, an effect partially reversible by chemical reduction of carbonyl groups. |
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