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Synthesis and in vitro activity of a hormone-diphtheria toxin fragment A hybrid |
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| Authors: | T N Oeltmann |
| Institution: | 1. Lab of Tissue Engineering, College of Life Sciences, Northwest University, Xi''an, China;2. Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi''an, China;3. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi''an, China |
| Abstract: | The synthesis and in vitro biological activity of a hybrid protein composed of intact human chorionic gonadotropin and fragment A of diphtheria toxin in a disulfide conjugate is reported. This hybrid retained greater than 90% of the binding ability of uncoupled hCG and was shown to be specifically toxic to a mouse Leydig cell tumor which binds hCG while being non-toxic towards cells which lack receptors for hCG. |
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