Polymorphism 192Q/R of the paraoxonase 1 gene in elderly men and long-lived people of the Tatar ethnic group |
| |
Authors: | V. V. Pauk I. A. Tuktarova T. R. Nasibullin L. P. Zueva A. Kh. Adelguzhina E. K. Khusnutdinova O. E. Mustafina |
| |
Affiliation: | (1) Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, Bashkortostan, 4500054, Russia |
| |
Abstract: | To study the molecular genetic basis of human aging and longevity, the allele and genotype frequencies of the 192Q/R polymorphism of PON1 were compared for ethnic Tatars of the younger (1–20 years), middle (21–55 years), elderly (56–74 years), senile (75–89 years), and long-lived (90–109 years) age groups (in total, 1116 people). The PON1 alleles were identified using PCR and restriction enzyme analysis. In the total samples, the frequencies of genotypes Q/Q, Q/R, and R/R were 46.15, 44.35, and 9.5%, respectively, and the frequencies of alleles Q and R were 68.32 and 31.68%, respectively. Some age groups significantly differed from each other in allele and genotype frequencies. The frequency of allele R in the senile group (28.46%) was significantly lower than in the younger group (37.42%, P = 0.009). However, the long-lived displayed significantly higher frequencies of allele R (P = 0.005) and genotype R/R (P = 0.01) as compared with the senile group. |
| |
Keywords: | ethnogenomics paraoxonase 1 PON1 allele polymorphism aging longevity Tatars |
本文献已被 SpringerLink 等数据库收录! |
|