Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human |
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| Authors: | Ruihua Ji Jiao Zhu Dan Wang Qian-Qian Sui Gillian E. Knight Geoffrey Burnstock Hongbin Yuan Zhenghua Xiang |
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| Affiliation: | 1.Department of Anesthesiology, Changzheng Hospital,Second Military Medical University,Shanghai,China;2.Department of Neurobiology, MOE Key Laboratory of Molecular Neurobiology, Ministry of Education, Neuroscience Research Centre of Changzheng Hospital,Second Military Medical University,Shanghai,People’s Republic of China;3.Autonomic Neuroscience Centre,University College Medical School,London,UK;4.Department of Pharmacology,Melbourne University,Melbourne,Australia;5.Florey Institute of Neuroscience and Mental Health,Melbourne,Australia |
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| Abstract: | With immunohistochemical and Western blot techniques, P2X1 receptors were detected in the whole mouse gastrointestinal tract and pancreatic islets of mouse and human. (1) δ Cells containing somatostatin (SOM) in the stomach corpus, small intestines, distal colon, pancreatic islets of both mouse and human express P2X1 receptors; (2) strong immunofluorescence of P2X1 receptors was detected in smooth muscle fibers and capillary networks of the villus core of mouse intestine; and (3) P2X1 receptor-immunoreactive neurons were also detected widely in both mouse myenteric and submucosal plexuses, all of which express SOM. The present data implies that ATP via P2X1 receptors is involved in SOM release from pancreatic δ cells, enteric neurons, and capillary networks in villi. |
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