Characterization of a novel wild-type t(wMPI) haplotype of the house mouse (Mus domesticus L.) from Peru] |
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| Authors: | I V Shustrova L I Chebykina |
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| Affiliation: | Severtzov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia. |
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| Abstract: | Data on molecular genetic analysis of the novel wild-type twMP1 haplotype found in a population of Mus domesticus from Peru are presented. Complementation attribution of the novel haplotype as well as fertility of heterozygotes and transmission ratio distortion (TRD) of the t-carrying chromosome in the progeny of the heterozygous males were studied. Molecular analysis was carried out by means of blot hybridization with the four t-specific probes (Tu48, Tu66, Tu119, and Tu122). Comparison of the results obtained with the data on the structure and properties of the t complexes permitted conclusion on the complete lethality of the haplotype described. |
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