Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers |
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| Authors: | Ohwada Tomohiko Nonomura Taro Maki Keisuke Sakamoto Kazuho Ohya Susumu Muraki Katsuhiko Imaizumi Yuji |
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| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. ohwada@mol.f.u-tokyo.ac.jp |
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| Abstract: | We found that the dehydroabietic acid structure is a new scaffold for chemical modulators of large-conductance calcium-activated K+ channels (BK channels). Structure-activity relationship (SAR) studies of the dehydroabietic acid derivatives and related non-aromatic compounds such as pimaric acid revealed the importance of the carboxyl functionality and an appropriate hydrophobic moiety of the molecules for BK channel-opening ability. |
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