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Skewed X Chromosome Inactivation and Trisomic Spontaneous Abortion: No Association |
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| Authors: | Dorothy Warburton Jennie Kline Ann Kinney Chih-yu Yu Stephen Brown |
| Affiliation: | 1 Department of Genetics and Development, Columbia University, New York, NY 10032, USA 2 Department of Pediatrics, Columbia University, New York, NY 10032, USA 3 Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA 4 Department of Epidemiology, Columbia University, New York, NY 10032, USA 5 Department of Biostatistics, Columbia University, New York, NY 10032, USA 6 Graduate School of Arts and Sciences, Columbia University, New York, NY 10032, USA 7 New York State Psychiatric Institute, New York, NY 10032, USA 8 Department of Obstetrics, Gynecology and Reproductive Science, The University of Vermont, Burlington, VT 05401, USA |
| Abstract: | Several studies suggest that highly skewed X chromosome inactivation (HSXI) is associated with recurrent spontaneous abortion. We hypothesized that this association reflects an increased rate of trisomic conceptions due to anomalies on the X chromosome that lead both to HSXI and to a diminished oocyte pool. We compared the distribution of X chromosome inactivation (XCI) skewing percentages (range: 50%–100%) among women with spontaneous abortions in four karyotype groups—trisomy (n = 154), chromosomally normal male (n = 43), chromosomally normal female (n = 38), nontrisomic chromosomally abnormal (n = 61)—to the distribution for age-matched controls with chromosomally normal births (n = 388). In secondary analyses, we subdivided the nontrisomic chromosomally abnormal group, divided trisomies by chromosome, and classified women by reproductive history. Our data support neither an association of HSXI with all trisomies nor an association of HSXI with chromosomally normal male spontaneous abortions. We also find no association between HSXI and recurrent abortion (n = 45). |
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