Experimental atherosclerosis in rabbits: Platelet aggregation, thromboxane A2 generation and anti-aggregatory potency of prostacyclin |
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| Authors: | A Zmuda A Dembinska-Kiec A Chytkowski RJ Gryglewski |
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| Institution: | Department of Pharmacology, Copernicus Academy of Medicine, 31-531 Cracow, 16 Grzegorzecka, Poland |
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| Abstract: | Experimental atherosclerosis in rabbits was associated with increased aggregation of their platelets to arachidonic acid, and with increased generation of thromboxane A2 by their platelet-rich plasma. A heightened susceptibility of platelets to the anti-aggregatory action of prostacyclin against the ADP-induced aggregation was also observed. It is concluded that in advanced atherosclerosis the platelet system is hypersensitive to biologically active metabolites of arachidonic acid. |
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