Common and uncommon immunoglobulin haplotypes among Lebanese communities |
| |
| Authors: | Gérard Lefranc Liliane Rivat Jean-Louis Serre Jean-Marc Lalouel Gilles Pison Jacques Loiselet Claude Ropartz Gerda de Lange Erna van Loghem |
| |
| Affiliation: | (1) Faculté française de Médecine et de Pharmacie, Beirut, Lebanon;(2) Unité 78 sur la Génétique des Protéines humaines, INSERM, F-76230 Bois-Guillaume, France;(3) Service de Génétique, Institut national d'Etudes démographiques, Paris, France;(4) International Reference Centre (WHO) for Human Immunoglobulin Genetic Markers, F-76230 Bois-Guillaume, France;(5) Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, The Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, Plesmanlaan 125, Amsterdam, The Netherlands;(6) Present address: Facultés de Pharmacie et de Médecine dentaire, Monastir, Tunisia;(7) Present address: Université de Rouen, France |
| |
| Abstract: | Summary Allotypes of IgG1, IgG2, IgG3, and IgA2 subclasses were investigated in seven Lebanese communities (three Moslem and four Christian). The Gm-Am haplotypes found were mainly those prevalent in Caucasians with a low frequency of haplotypes usually observed in Africans and Orientals. The difference between highlanders and lowlanders as expressed by G2m(23) was highly significant and suggested a possible adaptation to selective pressure related to the  2 genes, possibly due to endemic malaria in the past. Exceptional Gm-Am haplotypes were unambiguously determined by family studies. Some were characterized either by a deletion or a repression or, in contrast, by a partial or total duplication of genes. Two others had uncommon combinations of allotypes: Gm17;23;5,10,11,13,14A2m1, where G1m(17) was present without G1m(1); and Gm3;23;5,14A2m1, where the CH3 allotypes G3m(10,11,13) were lacking.To whom offprint requests should be sent |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
