Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism |
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Authors: | Nelson Eric J Connolly Jon McArthur Patrick |
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Affiliation: | Husson Science Research Institute, One College Circle, Bangor, ME 04401, USA. |
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Abstract: | This review focuses on the important physiological messenger, nitric oxide (NO), and its role in N-methyl-D-aspartate (NMDA) excitotoxicity. NO has been shown to be a key mediator of voltage-gated Ca(+2) transmembrane proteins. It remains unclear whether NO is implicated during hypoxia, or ischemic/reperfusion injuries as a neuroprotective or neurodegenerative factor. Excitotoxicity results from the excessive stimulation of excitatory glutamate receptors within the CNS. This review maintains that the feed-forward pathway precipitated by oxidative stress is the discriminating factor in the neuroprotective or neurodegenerative actions of NO. |
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Keywords: | Nitric oxide NMDA receptors S-nitrosylation Apoptosis Excitotoxicity |
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