Pore positioning: Current concepts in Pannexin channel trafficking |
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Authors: | Andrew KJ Boyce Ross T Prager Leigh E Wicki-Stordeur Leigh Anne Swayne |
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Affiliation: | 1.Division of Medical Sciences; Island Medical Program; University of Victoria; Victoria, British Columbia, Canada;2.Department of Biology; University of Victoria; Victoria, British Columbia, Canada;3.Department of Biochemistry and Microbiology; University of Victoria; Victoria, British Columbia, Canada;4.Department of Cellular and Physiological Sciences; University of British Columbia; Vancouver, British Columbia, Canada |
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Abstract: | Pannexins (Panxs) are a multifaceted family of ion and metabolite channels that play key roles in a number of physiological and pathophysiological settings. These single membrane large-pore channels exhibit a variety of tissue, cell type, and subcellular distributions. The lifecycles of Panxs are complex, yet must be understood to accurately target these proteins for future therapeutic use. Here we review the basics of Panx function and localization, and then analyze the recent advances in knowledge regarding Panx trafficking. We examine several intrinsic features of Panxs including specific post-translational modifications, the divergent C-termini, and oligomerization, all of which contribute to Panx anterograde transport pathways. Further, we examine the potential influence of extrinsic factors, such as protein-protein interactions, on Panx trafficking. Finally, we highlight what is currently known with respect to Panx internalization and retrograde transport, and present new data illustrating Panx1 internalization following an activating stimulus. |
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Keywords: | Pannexin 1 trafficking subcellular localization retrograde large-pore channels internalization glycosylation anterograde Panx C-terminus |
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