Cilia and coordination of signaling networks during heart development |
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Authors: | Karen Koefoed Iben R?nn Veland Lotte Bang Pedersen Lars Allan Larsen S?ren Tvorup Christensen |
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Affiliation: | 1.Department of Biology; University of Copenhagen; Copenhagen, Denmark;2.Wilhelm Johannsen Centre for Functional Genome Research; Department of Cellular and Molecular Medicine; University of Copenhagen; Copenhagen, Denmark |
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Abstract: | Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart disease. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development. |
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Keywords: | nodal cilia primary cilia signaling networks cardiomyogenesis stem cells heart development heterotaxy congenital heart diseases |
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