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A genetically engineered strain of Pseudomonas putida as a useful tool for identifying new therapeutic herbicides |
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| Authors: | Arias-Barrau Elsa Sandoval Angel Arcos Mario Arias Sagrario Naharro Germán Olivera Elías R Luengo José M |
| Affiliation: | 1. Department of Pharmaceutical Sciences, Maringá State University (UEM), Maringá, Paraná 87020900, Brazil;2. Department of Basic Health Sciences, Maringá State University (UEM), Maringá, Paraná 87020900, Brazil;3. Department of Chemistry, Faculty of Sciences, São Paulo State University (UNESP), Bauru, São Paulo 17033360, Brazil |
| Abstract: | A genetically engineered strain of Pseudomonas putida U designed for the identification of new therapeutic herbicides has been obtained. In this bacterium, deletion of the homogentisate gene cluster (hmgRABC) confers upon this mutant huge biotechnological possibilities since it can be used: (i) as a target for testing new specific herbicides (p-hydroxy-phenylpyruvate dioxygenase inhibitors); (ii) to identify new therapeutic drugs-effective in the treatment of alkaptonuria and other related tyrosinemia - and (iii) as a source of homogentisic acid in a plant-bacterium association. |
| Keywords: | Herbicides Homogentisic acid Pseudomonas putida Therapeutic |
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