Bioconversion of compactin into pravastatin by Streptomyces sp. |
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| Authors: | Joo-Woong Park Joo-Kyung Lee Tae-Jong Kwon Dong-Hee Yi Young-Jun Kim Seong-Hoon Moon Hyun-Hyo Suh Sang-Mo Kang Yong-Il Park |
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| Affiliation: | (1) Biotechnology Laboratory, Youngjin Pharmaceutical Co. Ltd., Pyungtaek-Si, 451-860, Korea;(2) Department of Microbial Engineering, Kon Kuk University, Seoul, 133-701, Korea;(3) Division of Biotechnology and The Collaborative Institute of Science and Technology, The Catholic University of Korea, 43-1, Yokkok 2-dong, Wonmi-gu, Bucheon City, Gyonggi-do, 420-743, Korea;(4) Department of Environmental Engineering, Chinju National University, Chinju, 660-758, Korea |
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| Abstract: | Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l–1 from 750 mg compactin l–1 in 24 h. By intermittent feeding of compactin into the culture medium, both the compactin concentration and its conversion increased to 2000 mg l–1 and 1000 mg pravastatin l–1, respectively, with the conversion rate of 10 mg l–1 h–1. Continuous feeding of compactin increased production of pravastatin to 15 mg l–1 h–1. |
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| Keywords: | bioconversion compactin cytochrome P-450 pavastatin Streptomyces sp. |
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