Ecto-phosphatases in protozoan parasites: possible roles in nutrition,growth and ROS sensing |
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Authors: | Daniela Cosentino-Gomes José Roberto Meyer-Fernandes |
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Institution: | 1.Instituto de Bioquímica Médica,Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitária,Rio de Janeiro,Brazil;2.Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INCTBEB), CCS, Bloco H, Cidade Universitária,Rio de Janeiro,Brazil |
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Abstract: | The cellular plasma membrane contains enzymes whose active sites face the external medium rather than the cytoplasm. The activities
of these enzymes, referred to as ecto-enzymes, can be measured using living cells. Ecto-phosphatases are ecto-enzymes that
presumably hydrolyze extracellular phosphorylated substrates, releasing free inorganic phosphate. Although, several alternative
functions have been suggested for these enzymes, such as participation in proliferation, differentiation, adhesion, virulence,
and infection, little is known about the physiological roles of these enzymes in protozoa parasites. In this review, we discuss
the principal features of ecto-phosphatases in protozoan parasites that are causative agents of important diseases such as
Chagas’ disease, leishmaniasis, amoebiasis, giardiasis, trichomoniasis and, sleeping sickness. |
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Keywords: | |
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