The effect of a GnRH antagonist pre-treatment,in the superovulation of goats |
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| Institution: | 1. Department of Animal Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran;2. Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;3. Department of Agronomy and Plant Breeding, Faculty of Agriculture, Shahrood University of Technology, Shahrood, Iran;4. Department of Genetic Engineering and Biotechnology, Research Center for Novel Technologies (BRNA), Shahrood University of Technology, Shahrood, Iran;5. Department of Reproduction, Animal Breeding Center, Karaj, Iran;6. Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;1. Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego Str 1A, 10-719 Olsztyn-Kortowo, Poland;2. Department of Gamete and Embryo Biology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-747 Olsztyn, Poland;1. Escuela de Medicina Veterinaria, Universidad Católica de Temuco, Temuco, Chile;2. Núcleo de investigación en Producción Alimentaria, Universidad Católica de Temuco, Temuco, Chile;3. Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;4. Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile;5. Programa de Doctorado en Ciencias Veterinarias, Escuela de Postgrado, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile;6. Ross University School of Veterinary Medicine, Basseterre, St. Kitts, West Indies;1. Laboratory of Animal Reproductive Science, College of Animal Science and Technology, Northeast Agricultural University, Harbin, China;2. National Key Laboratory of Animal Nutrition, Laboratory of Animal Embryonic Biotechnology, College of Animal Science and Technology, China Agricultural University, Beijing, China;3. Animal Husbandry and Veterinary Institute, Heilongjiang Academy of Land Reclamation Sciences, Harbin, China;1. Leblanc Reproduction Center, Rood and Riddle Equine Hospital, Lexington, Kentucky;2. Department of Veterinary Clinical Science and Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, Washington |
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| Abstract: | The effect of a short pre-treatment with a GnRH antagonist (Cetrorelix acetate) and the induced superovulation response was evaluated in goats. A total of 16 nanny goats were allocated to two groups. The goats in the antagonist treatment group (n = 8) received 6 doses of the GnRH antagonist, once daily, as a pre-treatment to superovulation. The does in the control group were provided with saline only. Natural mating was implemented using three fertile bucks. Large follicles on the ovaries were detected via ultrasound at 3.5 MHz. All goats were laparotomized and the CL's and cystic follicles visually recorded. Embryos were recovered via flushing and recorded 6 days after sponge removal. The number of large follicles induced and embryos produced were significantly increased by treatment. However, no differences were noted regarding the numbers of cystic follicles, indicating a lack of negative side-effects following the use of GnRH. In general, the number of large follicles and embryos were significantly (P < 0.05) higher in the treated group. It was demonstrated that a GnRH antagonist treatment can improve the superovulatory response by 64% and embryo recovery rate by 90% in goats. |
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