Engineering cytokine receptors to control cellular functions |
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| Affiliation: | 1. European Competence Center for Ovarian Cancer (EKZE), Department of Gynecology, Charité – University Medicine of Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany;2. Dresden International University, Division of Health Care Sciences, Center for Clinical Research and Management Education, Freiberger Str. 37, 01067 Dresden, Germany;3. Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307 Dresden, Germany;1. Department of Biochemistry & Molecular Biology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan;2. Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan |
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| Abstract: | Cytokine receptors function as an interface between a cell and the extracellular milieu, and play a pivotal role in cell fate, because they recognize specific ligands via their extracellular domain and trigger signal transduction via their intracellular domain. Recent advances in unraveling the mechanism of cytokine receptor-mediated signal transduction have allowed us to engineer cytokine receptors with distinct functions, which have a potential for use in biotechnology. This paper reviews the history and current topics of receptor engineering. |
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